Source: Circulation | Posted 8 years ago
Attenuation of hypothalamic-pituitary-adrenocortical hyperactivity in depressed patients by mirtazapine
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German clinicians have found that mirtazapine rapidly attenuates the dysregulation of the hypothalamic-pituitary-adrenocortical (HPA) system seen in depressed patients.
They note, however, that this effect of mirtazapine is not necessarily related to clinical improvement.
Previous research suggested that dysregulation of the HPA system might play an important role in the pathophysiology of depression, and that normalization of HPA axis hyperactivity precedes successful treatment with antidepressants, write Dr. Cornelius Sch
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