To print: Select File and then Print from your browser's menu --------------------------------------------------------------------------------------- Title: DG DISPATCH - ISH: Aspirin Helps Prevent Preeclampsia URL: http://www.pslgroup.com/dg/1DE4BA.htm Doctor's Guide August 25, 2000
By Lara Pullen Special to DG News
CHICAGO, IL -- August 25, 2000 -- Women who are at high risk for developing preeclampsia may significantly decrease their incidence of preeclampsia and complications of childbirth if they take 100 mg of aspirin at bedtime, research suggests.
At the 18th Scientific Meeting of the International Society of Hypertension (ISH), Dr. Ramon Hermida of the University of Vigo, Spain, presented the results of a study designed to determine under what circumstances aspirin could effectively prevent preeclampsia.
The study included 286 pregnant women (156 first-time pregnancies) and is one of the largest studies conducted thus far in the field.
Women were randomly assigned to one of six groups -- placebo on awakening, aspirin on awakening, placebo eight hours after awakening, aspirin eight hours after awakening, placebo before bedtime, aspirin before bedtime.
Blood pressure was automatically monitored every 20 minutes. Results indicate that the bedtime dose of aspirin had a pronounced and statistically significant effect on the 24-hour mean blood pressure.
There was minimal to no effect on blood pressure when the aspirin was taken earlier in the day -- either upon awakening or eight hours after awaking. Aspirin had no effect on the women's heart rate.
The author concluded that 100 mg/day of aspirin taken prior to bedtime was not associated with any problems in pregnancy and, in fact, was able to decrease blood pressure in women who were at risk for preeclampsia.
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