To print: Select File and then Print from your browser's menu --------------------------------------------------------------------------------------- Title: DG DISPATCH - AACAP: Sertraline Effective In Children With OCD URL: http://www.pslgroup.com/dg/13D2FE.htm Doctor's Guide October 22, 1999
By Lara Pullen Special to DG News
CHICAGO, IL -- October 22, 1999 -- Obsessive compulsive disorder (OCD) affects approximately one in 200 young people. A multi-center, randomized, placebo-controlled trial has demonstrated that the selective serotonin reuptake inhibitor (SSRI), sertraline, is a safe and effective treatment for young people with this condition.
Dr. Edwin Cook of the University of Chicago presented the results of a 52-week clinical trial Thursday (Oct. 21) at the 46th annual meeting of the American Academy of Child and Adolescent Psychiatry (AACAP). The purpose of the trial was to evaluate the long-term safety and efficacy of sertraline in children and adolescents with OCD.
The study included 137 children six to 18 years who were diagnosed with OCD and who had completed an initial 12-week, multi-center, double-blind comparison of placebo and sertraline. Sertraline dosage was titrated upwards in 25 mg weekly increments from an initial dose of 25 mg (age six-12 years) or 50 mg weekly doses from an initial dose of 50 mg (age 13-18) based upon clinical response. The maximum dosage used was 200 mg.
There was a statistically significant improvement in sertraline-treated patients over the course of the study. In addition, sertraline was well tolerated with an adverse event profile similar to that seen in adults. The adverse events tended to occur early in the course of treatment and decreased markedly as the trial progressed. --------------------------------------------------------------------------------------------- Copyright © 1999 P\S\L Consulting Group Inc. All rights reserved. Republication or redistribution of P\S\L content is expressly prohibited without the prior written consent of P\S\L. P\S\L shall not be liable for any errors, omissions or delays in this content or any other content on its sites, newsletters or other publications, nor for any decisions or actions taken in reliance on such content. --------------------------------------------------------------------------------------------- This news story was printed from *Doctor's Guide to the Internet* located at http://www.docguide.com --------------------------------------------------------------------------------------- Return to News Story Page This site is maintained by webmaster@pslgroup.com Please contact us with any comments, problems or bugs. All contents Copyright (c) 1998 P\S\L Consulting Group Inc. All rights reserved.