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Title: Hay Fever May Be Best Treated With Self-Adjusted Dosing
URL: http://www.pslgroup.com/dg/22DF86.htm
Doctor's Guide
October 1, 2008

ALEXANDRIA, Va -- October 1, 2008 -- Hay fever is best controlled through a course of patient-adjusted dosing, according to new research published in the September issue of Otolaryngology-Head and Neck Surgery.

During the study, hay fever was observed in 69 patients, who were then treated over the course of 28 days with the intranasal corticosteroid triamcinolone acetonide. Patients with mild symptoms were instructed to use the treatment only after symptoms occurred once a day. Patients with more severe symptoms were told to continue morning daily dosage until they were symptom-free for 24 hours.

However, as opposed to the normally prescribed once-daily dose, patients were instructed to adjust their use pattern based on the frequency and severity of symptoms, and it was emphasised to them not to tolerate any mild or transient symptoms. As a result, during the course of the study, all patients saw improvement in their nasal symptom scores (which include blocked sinuses, rhinorrhoea/runny nose, sneezing, and nasal itching).

The authors believe that this self-adjusted dose regimen, which allows patients to increase or decrease the regularity of their dose based on their level of symptoms, the intranasal corticosteroids remain effective, while the treatment prevents priming responses and increased sensitivity that might otherwise occur over time.

As a result, the authors determined that almost maximal symptomatic control could be achieved with three-fourths of the recommended regular once-daily dose by varying the daily dosage according to the severity of disease. They believe this approach would be a reasonable way to optimise both treatment efficacy and patient compliance.

SOURCE: American Academy of Otolaryngology -- Head and Neck Surgery

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