To print: Select File and then Print from your browser's menu --------------------------------------------------------------------------------------- Title: Optimal Systemic and Splanchnic Hemodynamic State After Living-Donor Liver Transplantation URL: http://www.pslgroup.com/dg/217222.htm Doctor's Guide November 14, 2007
BEIJING, CHINA -- November 14, 2007 -- Almost all adult recipients who undergo LDLT develop liver cirrhosis with long-term portal hypertension. Portal hypertension results in vascular dilatation and collateral pathways. Thus, various alterations in systemic hemodynamics and splanchnic circulation occur, and adult recipients often present characteristic hemodynamics before LDLT. A research group from Kyoto University Hospital, Japan (Hori T, Yagi S, Iida T, Uemoto S) led by Tomohide Hori, MD, PhD, Department of Transplantation, Divisions of Hepato-pancreato-biliary Surgery and Transplantation and Pediatric Surgery, Kyoto University Hospital, 54 Shogoinkawara-cho, Sakyo-ku, Kyoto, non-invasively investigated systemic hemodynamics and splanchnic circulation after LDLT in 30 adult recipients with liver cirrhosis who underwent LDLT (2003-2006), and their research has been published on the November issue 28 of World Journal of Gastroenterology. The study ascertained the correlation between systemic hemodynamics and splanchnic circulation, and clarified how systemic hemodynamic state impacts on local graft circulation. Interestingly, the results of splanchnic circulatory parameters in their current study reveal systemic hemodynamics correlate well with splanchnic circulation, and that subtle disorders of optimal systemic hyperdynamic state easily influence portal venous flow rather than hepatic arterial flow. Moreover, they also identify what hemodynamic state is necessary for excellent clinical outcomes corresponding to good graft functions. Dr. Hori demonstrated the persistence of characteristic systemic hyperdynamic state is indispensable for cirrhotic recipients, even after LDLT, by using a device that can non-invasively analyze the kinetics of indocyanine green, and he is doing further study now at Kyoto University Hospital. Since portal venous flow has been shown to have a large influence on liver regeneration after LDLT, successful clinical outcomes in cirrhotic LDLT recipients are attributed to optimal stability of systemic hyperdynamic state yielding sufficient portal venous flow. REFERENCE: Hori T, Yagi S, Iida T, Taniguchi K, Yamagiwa K, Yamamoto C, Hasegawa T, Yamakado K, Kato T, Saito K, Wang L, Torii M, Hori Y, Takeda K, Maruyama K, Uemoto S. Stability of cirrhotic systemic hemodynamics ensures sufficient splanchnic blood fl ow after living-donor liver transplantation in adult recipients with liver cirrhosis. World J Gastroenterol 2007; 13(44): 5918-5925 http://www.wjgnet.com/1007-9327/13/5918.asp SOURCE: World Journal of Gastroenterology --------------------------------------------------------------------------------------------- Copyright © 1999 P\S\L Consulting Group Inc. All rights reserved. Republication or redistribution of P\S\L content is expressly prohibited without the prior written consent of P\S\L. P\S\L shall not be liable for any errors, omissions or delays in this content or any other content on its sites, newsletters or other publications, nor for any decisions or actions taken in reliance on such content. --------------------------------------------------------------------------------------------- This news story was printed from *Doctor's Guide to the Internet* located at http://www.docguide.com --------------------------------------------------------------------------------------- Return to News Story Page This site is maintained by webmaster@pslgroup.com Please contact us with any comments, problems or bugs. All contents Copyright (c) 1998 P\S\L Consulting Group Inc. All rights reserved.