To print: Select File and then Print from your browser's menu --------------------------------------------------------------------------------------- Title: Cancer Detection at Repeat Biopsy Higher in Patients With Inflammation at Initial Biopsy: Presented at CURy URL: http://www.pslgroup.com/dg/21C85A.htm Doctor's Guide February 5, 2008
By Chris Berrie BARCELONA, SPAIN -- February 5, 2008 -- Inflammation at first biopsy is associated with a significant risk for future cancer detection on a repeat biopsy in the presence of increasing prostate-specific antigen (PSA), according to a retrospective review of a prospectively recorded prostate biopsy database presented here at the World Congress on Controversies in Urology (CURy). Although it has been recognised that high-grade prostatic intraepithelial neoplasia (PIN) is a risk factor for development of prostate adenocarcinoma, it is not known whether inflammation plays a role in prostate cancer, according to coinvestigator Uwais Mufti, a Senior House Officer, Department of Urology, Princess Alexandra Hospital, Harlow, Essex, England, United Kingdom. This study was conducted to analyze histological factors in an initial transrectal ultrasound (TRUS) prostate biopsy that are predictive of a diagnosis of prostate cancer following a second biopsy, Dr. Mufti indicated in a presentation February 1. Of the 1,160 patients in the database of prostate biopsies over a 2.5-year period, 119 patients underwent repeat biopsy. Their first and second biopsy data indicated mean numbers of cores of 14 and 16, mean PSA levels of 10.7 and 12.3 ng/mL, and mean prostatic volumes of 54.2 and 58.8 mL, respectively. Mean time interval between biopsies was 13 months. These patients had mean increase in PSA level between biopsies of 1.48 ng/mL; mean percentage increase in PSA that led to repeat biopsy was 26.4%. Patients' analyses were divided according to five histological groups: benign (n = 50); high-grade PIN (n = 31); inflammation (n = 16); atypical small acinar proliferation (ASAP; n = 14); and minimal (<1 mm) adenocarcinoma (n = 8). Detection of cancers on repeat biopsy saw 14% for the originally benign group, 29% for high-grade PIN (P =.08), 38% for inflammation (P =.04), 21% for ASAP (P =.37), and 25% for adenocarcinoma (P =.36). Therefore, this study suggests that in patients undergoing repeat biopsies for detection of prostate cancer, the only significant predictive factor at first biopsy for cancer detection at second biopsy is inflammation. Dr. Mufti concluded, "Clinicians who have to follow-up these patients who have inflammation at their first prostate biopsy must make sure to follow them up, and if their PSA continues to go up, they may need a rebiopsy to make sure there is no cancer." [Presentation title: Cancer Detection at Repeat Biopsy Is Significantly Higher in Patients Who Have Inflammation on Initial Biopsy. Poster 12] --------------------------------------------------------------------------------------------- Copyright © 1999 P\S\L Consulting Group Inc. All rights reserved. Republication or redistribution of P\S\L content is expressly prohibited without the prior written consent of P\S\L. P\S\L shall not be liable for any errors, omissions or delays in this content or any other content on its sites, newsletters or other publications, nor for any decisions or actions taken in reliance on such content. --------------------------------------------------------------------------------------------- This news story was printed from *Doctor's Guide to the Internet* located at http://www.docguide.com --------------------------------------------------------------------------------------- Return to News Story Page This site is maintained by webmaster@pslgroup.com Please contact us with any comments, problems or bugs. All contents Copyright (c) 1998 P\S\L Consulting Group Inc. All rights reserved.