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Title: Respiratory-Gated Radiotherapy Reduces Need for Repeat Planning: Presented at ELCC
URL: http://www.pslgroup.com/dg/2205FA.htm
Doctor's Guide
April 29, 2008

By Timothy A. O'Leary

GENEVA -- April 29, 2008 -- Use of respiratory-gated radiotherapy (RGRT) in patients with locally advanced lung cancer reduces the need to adapt or modify radiotherapy treatment plans, researchers reported here at the 1st European Lung Cancer Conference (ELCC).

Jason Pantarotto, MD, Radiation Oncologist, VU University Medical Center, Amsterdam, Netherlands, and his collaborators designed their trial to evaluate whether adaptive modification of RGRT treatment plans was needed in patients receiving concurrent chemotherapy and radiotherapy.

"Our preliminary results suggest that adaptive radiotherapy has a limited role when RGRT is used to reduce toxicity," he said in his presentation on April 25.

Eligible patients underwent a repeat planning scan after receiving 15 fractions of radiotherapy. The repeat scan was coregistered with the initial scan and a new planning target volume (PTV) was generated, he said.

Coverage of the repeat PTV was evaluated by applying the original treatment plan to the second scan and recalculating the dose. No treatment plans were modified.

"Good coverage of repeat PTVs was seen using the initial plan, with 3 patients maintaining 100% coverage by the 95% isodose volume and others showing only slight deviations [maximum volume not covered of 1.4%]," Dr. Pantarotto said. "Consequently, no treatment plans were modified. Lung and cord doses were not significantly different on the repeat scan."

He added, "The changes in PTV after 15 fractions of [chemoradiotherapy] do not appear to be clinically significant in terms of geometric or dosimetric miss."


[Presentation title: Adaptive Radiotherapy Planning During Image-Guided Concurrent CT-RT for Lung Cancer: Preliminary Analysis of a Prospective Clinical Study. Abstract 247O]

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