To print: Select File and then Print from your browser's menu --------------------------------------------------------------------------------------- Title: DG DISPATCH - ISH: Droloxifene Lowers Blood Pressure In Healthy Postmenopausal Women URL: http://www.pslgroup.com/dg/1DDFBE.htm Doctor's Guide August 23, 2000
By Lara Pullen Special to DG News
CHICAGO, IL -- August 23, 2000 -- Droloxifene is the first selective estrogen receptor modulator (SERM) shown to lower blood pressure in healthy postmenopausal women.
At the 18th Scientific Meeting of the International Society of Hypertension (ISH), Dr. K. Bridget Brosnihan of the Wake Forest University School of Medicine, Winston-Salem, NC, presented the results of a study which compared the effects on blood pressure of conjugated equine estrogen and the tamoxifen analogue, droloxifene.
The study included 24 healthy postmenopausal women between the ages of 50 and 65 years. The women had fasting low-density lipopolysaccharide levels of less than 200 mg/dL and triglyceride levels of less than 400 mg/dL.
The women had an average systolic blood pressure (SBP) of 133 and an average diastolic blood pressure (DBP) of 72.
While conjugated equine estrogen had no effect on blood pressure levels, droloxifene significantly reduced blood pressure levels (5 percent decrease for SBP and 8 percent decrease for DBP).
Both estrogen and droloxifene increased the levels of plasma angiotensin II, although neither had a significant effect on angiotensin I.
Dr. Brosnihan noted that these results were seen in healthy women with no cardiovascular risk and the research needs to be expanded to include a larger group of women with varying degrees of cardiovascular risk. --------------------------------------------------------------------------------------------- Copyright © 1999 P\S\L Consulting Group Inc. All rights reserved. Republication or redistribution of P\S\L content is expressly prohibited without the prior written consent of P\S\L. P\S\L shall not be liable for any errors, omissions or delays in this content or any other content on its sites, newsletters or other publications, nor for any decisions or actions taken in reliance on such content. --------------------------------------------------------------------------------------------- This news story was printed from *Doctor's Guide to the Internet* located at http://www.docguide.com --------------------------------------------------------------------------------------- Return to News Story Page This site is maintained by webmaster@pslgroup.com Please contact us with any comments, problems or bugs. All contents Copyright (c) 1998 P\S\L Consulting Group Inc. All rights reserved.