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Title: High BMI Increases Risk of Colorectal Adenomas
URL: http://www.pslgroup.com/dg/22983E.htm
Doctor's Guide
August 20, 2008

BALTIMORE, Md -- August 20, 2008 -- A scientific study in the August issue of the American Journal of Gastroenterology examines the association between obesity and the risk of colorectal adenomas.

Researchers at the University of Tokyo, Tokyo, Japan, and Kameda General Hospital, Kamogawa City, Japan, examined the effect of body weight on the incidence of colorectal adenoma in 7,963 Japanese patients who underwent colonoscopy between 1991 and 2003. Patients who had a family history of colorectal cancer, colorectal polyps, inflammatory bowel disease, or colorectal surgery or who took nonsteroidal anti-inflammatory drugs (NSAIDs) were excluded from the study.

In this cross-sectional study, patients were classified into 4 groups according to their body mass index (BMI). Researchers found 20.7% of patients had at least 1 colorectal adenoma. It is important to note that as BMI increased, so did the prevalence of colorectal adenomas.

In a separate cohort analysis, 2,568 patients from the initial study underwent a second colonoscopy after 1 year to compare the effect of body weight changes on the development of new colorectal adenomas. The incidence rates of colorectal adenoma were 9.3% in patients who lost 5% or more in body weight, 16.2% in patients who gained 5% or more in body weight, and 17.1% in patients who neither gained nor lost weight.

Weight loss was associated with lowered incidence of adenoma, independent of gender, age, initial colonoscopic findings, and initial BMI. Based on their findings, the authors suggest that controlling body weight may decrease the risk of developing colorectal adenomas.

"The magnitude of the obesity epidemic," says Amy E. Foxx-Orenstein, DO, of the American College of Gastroenterology, "adds a staggering burden to our current healthcare system." This study points to the "serious potential risks of GI disease for individuals who are overweight or obese."


SOURCE: American College of Gastroenterology

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