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Title: Young Men With Type 2 Diabetes Have Low Testosterone Levels, May Affect Fertility
URL: http://www.pslgroup.com/dg/22A0CE.htm
Doctor's Guide
August 27, 2008

BUFFALO, NY -- August 27, 2008 -- Young men with type 2 diabetes have significantly low levels of testosterone, which could have a critical effect on their quality of life and on their ability to father children, according to a study published early online and in an upcoming issue of Diabetes Care.

"These new findings have several clinical implications besides the impairment of sexual function in these young men," said senior author Paresh Dandona, PhD, Department of Medicine, University at Buffalo and Millard Fillmore Hospital of Kaleida Health, Buffalo, New York.

"The lack of testosterone during these critical years may lead to diminished bone mass and the lack of development or loss of skeletal muscle. In addition, these patients may gain more weight and become more insulin resistant."

Dr. Dandona also noted that patients with low testosterone and type 2 diabetes have been shown to have very high concentrations of C-reactive protein.

The study included 38 men with type 1 diabetes aged 18 to 25 years (mean age, 26 years) and 24 men within the same age range with type 2 diabetes (mean age, 27 years).

Results showed that men with type 2 diabetes had half the amount of total and free testosterone in their blood as their type 1 counterparts.

Using the amount of free testosterone considered normal in men, 8 out of the 24 men with type 2 diabetes had below-normal concentrations.

However, when using the normal range for men of their age, 14 out of the 24 (58%) had lower than normal testosterone levels. Type 1 diabetics had normal levels of total and free testosterone for their age group.

Furthermore, patients with below-normal testosterone also had low levels of luteinising hormone and follicle-stimulating hormone.

"While obesity contributes to the association of type 2 diabetes and hypogonadotropic hypogonadism (HH), the association is not dependent entirely on obesity," said Dr. Dandona.

"Whether obesity or insulin resistance is the major determinant of HH has to be addressed in future studies, and the pathogenesis of HH needs to be defined."

SOURCE: University at Buffalo

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