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Title: Women With Symptoms in Lower Urinary Tract Have Increased Rate of Sexual Dysfunction: Presented at EAU
URL: http://www.pslgroup.com/dg/21EE1A.htm
Doctor's Guide
March 30, 2008


By Jill Stein

MILAN, Italy -- March 30, 2008 -- The presence of lower urinary tract symptoms (LUTS) in women sets the stage for future sexual dysfunction, according to information released here on March 28 at the 23rd Annual European Association of Urology (EAU) Congress.

Con Kelleher, MBBS, MD, MRCOG, Consultant in Obstetrics and Gynaecology, Guy's and St. Thomas' Hospital NHS Foundation Trusts, London, United Kingdom, described findings demonstrating that the prevalence of sexual dysfunction is 3 times higher in women with LUTS compared with women without LUTS (1.5% vs 0.5%). These findings come from a population-based study using a database that contains records on nearly 1.5 million women from 333 general practitioners' practices.

Dr. Kelleher and colleagues analysed several variables in women 18 years of age or older over a recent 6-year period. These variables included the following: recorded sexual dysfunction; diagnosis of overactive bladder; storage LUTS (including urgency, frequency, urgency urinary incontinence, and nocturia); and voiding LUTS (including slow stream, hesitancy, straining, terminal dribble, intermittent stream, splitting, or spraying).

There was a marked increased in the overall prevalence of overactive bladder, storage, and voiding LUTS, and sexual dysfunction during the study period (30,497 total cases in 2000 vs 66,965 cases in 2006).

The prevalence of voiding LUTS specifically increased from 279 cases in 2000 to 841 in 2006, while cases of sexual dysfunction increased from 2,626 to 6,843 in the same time period.

The mean age for LUTS cases was 53 years, while the mean age for sexual dysfunction was 39 years, with an adjusted odds ratio of 2.15 (95% confidence interval) for sexual dysfunction in women with LUTS compared with women with no LUTS adjusted for age.

Despite a difference in the mean age of prevalent cases, LUTS was a highly significant predictor of sexual dysfunction.

Women between 30 and 60 years of age were significantly more likely to report sexual dysfunction than their younger and older counterparts.

The data suggest that the relationship between sexual dysfunction and LUTS/overactive bladder should be considered in women when diagnosing and treating these conditions, the investigators advised.

Although the impact of storage and voiding LUTS on sexual dysfunction in men has previously been described, the impact of these symptoms on sexual dysfunction in women has remained unclear, Dr. Kelleher observed.

Funding for this study was provided by Pfizer Inc.

[Presentation title: Increased Sexual Dysfunction in Women With LUTS, Including OAB in a UK General Practice Setting: Analyses From the THIN Database. Abstract 875]

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