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Title: Nocturia Not Usually Associated With Overactive Bladder: Presented at EAU
URL: http://www.pslgroup.com/dg/21ED2A.htm
Doctor's Guide
March 27, 2008


By Jill Stein

MILAN, Italy -- March 27, 2008 -- Most cases of nocturia occur independently of overactive bladder (OAB), according to data released at the 23rd Annual European Association of Urology (EAU) Congress.

Kari Tikkinen, MD, Staff Urologist, Tampere University Hospital and University of Tampere, Tampere, Finland, and colleagues assessed the impact of nocturia on health-related quality of life by analysing responses to questionnaires completed by about 3,600 subjects aged 18 to 70 years.

Subjects were drawn randomly from a population register of individuals living in Finland. OAB and nocturia frequency were assessed using the Danish Prostatic Symptom Questionnaire and the American Urological Association Symptom Index. Age-standardised prevalence with 95% confidence intervals was calculated using the population structure of Finland. The effect of age on perceived bother was analysed using linear-by-linear association. Health-related quality of life was measured by using the generic 15D instrument.

One of every 6 people with nocturia reported OAB, while 4 of 5 respondents with OAB reported nocturia, Dr. Tikkinen reported in a presentation on March 26.

Increasing nocturia was associated with increased prevalence of OAB.

Subjects with OAB reported at least 4 times more nocturia than those without OAB.

Data also showed that both nocturia and OAB increased with age. What's more, the relation between nocturia and OAB appeared similar across age groups. Overall, the more severe the nocturia, the stronger the relationship with OAB.

Dr. Tikkinen said the validity of these results is bolstered by the high response rate (about 60% of the target population) and the representative study population in terms of age distribution, and sociodemographic, anthropometric, and reproductive factors.

[Presentation title: Bother and Impact of Nocturia on Health-Related Quality of Life: A Population-Based Study. Abstract 1017]

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