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Title: Gene Variation Associated With Decreased Risk of Colorectal Cancer
URL: http://www.pslgroup.com/dg/22DEA6.htm
Doctor's Guide
September 30, 2008

CHICAGO -- September 30, 2008 -- Variation of the adiponectin gene is associated with a decreased colorectal cancer risk, according to a study in the October 1 issue of the Journal of the American Medical Association.

"While there is evidence of an association between circulating adiponectin levels and colorectal cancer risk, no association between genes of the adiponectin pathway and colorectal cancer have been reported to date," the authors wrote.

Virginia G. Kaklamani, MD, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, and colleagues conducted a study to determine the association between variations of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) genes with colorectal cancer risk.

The study consisted of 2 case-control studies including patients with a diagnosis of colorectal cancer and controls without cancer. Case-control study 1 included a total of 441 patients with colorectal cancer and 658 controls; both groups were of Ashkenazi Jewish ancestry and from New York. Case-control study 2 included 199 patients with colorectal cancer and 199 controls from Chicago, matched 1:1 for sex, age, and ethnicity.

"In this clinic-based, case-control analysis, we found an association between 1 single-nucleotide polymorphism [SNP] of the ADIPOQ and colorectal cancer risk in 2 separate case-control studies, as well as in the combined analysis of both studies after adjustment for age, sex, and other SNPs," the authors wrote.

They add that the findings suggest that the ADIPOQ gene may harbour SNPs/mutations susceptible to modify colorectal cancer risk.

"If these exciting results can be confirmed in other studies, the adiponectin axis may emerge as an important modifier of colorectal cancer risk. Future studies will need to address the potential impact of adiponectin and its SNPs in the prognosis of colorectal cancer and also may be incorporated in genetic risk models for the disease," they said.

SOURCE: Journal of the American Medical Association

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