To print: Select File and then Print from your browser's menu --------------------------------------------------------------------------------------- Title: Testosterone Decreases Fatigue, Improves Mood In Men With HIV, Says Study URL: http://www.pslgroup.com/dg/A489E.htm Doctor's Guide August 17, 1998
WASHINGTON, DC -- Aug. 17, 1998 -- Testosterone injections can reduce fatigue and improve mood among men who test positive for HIV, including those with full-blown AIDS, investigators have discovered. With improved antiviral treatments, more people with HIV are considering a return to work, but fatigue is often a barrier, writes Glenn Wagner, PhD, of the New York State Psychiatric Institute and colleagues in this month's issue of General Hospital Psychiatry. "Effective treatments for fatigue, such as testosterone, are particularly important for enhancing the quality of life and functioning for people living with HIV." One potential cause of fatigue is a deficiency of testosterone, which is the most common hormone abnormality among men with HIV, the investigators explain. Another potential cause of fatigue is depressed mood. In fact, fatigue is one factor used to diagnose depression. The researchers tested the effects of biweekly injections of testosterone in 66 HIV-positive men with clinical hypogonadism -- a condition marked by low interest in sex and one or more other symptoms, including depressed mood, low energy or weight loss. About three-quarters of the men were diagnosed with AIDS and about half were on disability. After 12 weeks, Dr. Wagner and his colleagues found that energy levels in 79 percent of the men were much improved. Men who responded to testosterone injections also reported greater enjoyment and satisfaction with their lives. The researchers say they were unable to determine whether testosterone treatments boosted energy levels directly or whether its effects on energy levels were indirect, by relieving depression, which is frequently accompanied by fatigue. "Improvement in energy level was almost always accompanied by improvement in mood," the investigators report. "It seems likely that for some, fatigue may be a symptom of depression, whereas for others, fatigue and its debilitating effect on functioning may result in depression or psychological distress." Testosterone treatments were generally well-tolerated by the men. Some experienced side effects, including irritability, acne and hair loss, but none discontinued treatment because of them. The long-term effects of testosterone treatment remain unknown, they write. --------------------------------------------------------------------------------------------- Copyright © 1999 P\S\L Consulting Group Inc. All rights reserved. Republication or redistribution of P\S\L content is expressly prohibited without the prior written consent of P\S\L. P\S\L shall not be liable for any errors, omissions or delays in this content or any other content on its sites, newsletters or other publications, nor for any decisions or actions taken in reliance on such content. --------------------------------------------------------------------------------------------- This news story was printed from *Doctor's Guide to the Internet* located at http://www.docguide.com --------------------------------------------------------------------------------------- Return to News Story Page This site is maintained by webmaster@pslgroup.com Please contact us with any comments, problems or bugs. All contents Copyright (c) 1998 P\S\L Consulting Group Inc. All rights reserved.