To print: Select File and then Print from your browser's menu --------------------------------------------------------------------------------------- Title: MicroRNAs Used to Diagnose and Classify Renal-Cell Carcinoma: Presented at ASCP URL: http://www.pslgroup.com/dg/22F26A.htm Doctor's Guide October 20, 2008
By Maggie Schwarz BALTIMORE, Md -- October 20, 2008 -- The expression profile of unique microribonucleic acids (microRNAs) may be useful in the diagnosis and prognosis of papillary renal-cell carcinoma, clear-cell renal-cell carcinoma, and chromophobe renal-cell carcinoma, according to research presented here at the American Society for Clinical Pathology (ASCP) 2008 Annual Meeting. "This is the first study to find a role of microRNA in these 3 types of renal-cell carcinoma," announced Gary Tozbikian, MD, University of Pennsylvania, Philadelphia, Pennsylvania, in a presentation on October 17. MicroRNAs modulate gene expression and are differentially expressed between a tumour and corresponding normal kidney tissue. Dr. Tozbikian and colleagues identified a distinct subset of microRNAs in the 3 categories of tumours. In papillary renal-cell carcinoma, 4 microRNAs were up-regulated and 2 down-regulated. In clear-cell renal-cell carcinoma, 7 microRNAs were up-regulated and 2 down-regulated. In chromophobe renal-cell carcinoma, 20 microRNAs were up-regulated and 3 down-regulated. Nine microRNAs were differentially expressed between chromophobe and papillary renal-cell carcinomas. Reverse-transcriptase polymerase chain reaction confirmed the results, using 6 probes for microRNA. Formalin-fixed paraffin-embedded tissue can be used to study microRNA profiles, Dr. Tozbikian explained. He added that the diagnostic utility of microRNAs merits study in the classification of renal-cell carcinoma. [Presentation title: MicroRNA Profiles of Papillary, Chromophobe, and Conventional Renal Cell Carcinomas.] --------------------------------------------------------------------------------------------- Copyright © 1999 P\S\L Consulting Group Inc. All rights reserved. Republication or redistribution of P\S\L content is expressly prohibited without the prior written consent of P\S\L. P\S\L shall not be liable for any errors, omissions or delays in this content or any other content on its sites, newsletters or other publications, nor for any decisions or actions taken in reliance on such content. --------------------------------------------------------------------------------------------- This news story was printed from *Doctor's Guide to the Internet* located at http://www.docguide.com --------------------------------------------------------------------------------------- Return to News Story Page This site is maintained by webmaster@pslgroup.com Please contact us with any comments, problems or bugs. All contents Copyright (c) 1998 P\S\L Consulting Group Inc. All rights reserved.