To print: Select File and then Print from your browser's menu --------------------------------------------------------------------------------------- Title: DG DISPATCH - AACAP: Guanfacine Effective For AD/HD And Tic Disorder URL: http://www.pslgroup.com/dg/13E79E.htm Doctor's Guide October 26, 1999
By Lara Pullen Special to DG News
CHICAGO, IL -- October 26, 1999 -- Although stimulants are the first line of treatment for children with attention deficit/hyperactivity disorder (AD/HD), approximately 30 percent of children fail to respond to stimulants and may demonstrate de novo emergence or worsening of tics following stimulant exposure. Guanfacine appears to be a safe and effective treatment for these children.
At the 46th annual meeting of the American Academy of Child and Adolescent Psychiatry, Dr. Lawrence D. Scahill, of the Yale Child Study Center, described the results of an eight-week, randomized, placebo-controlled trial. The purpose of the trial was to evaluate the efficacy and safety of guanfacine in children with AD/HD and a tic disorder.
The trial comprised 34 medication-free subjects (31 boys and 3 girls) ranging in age from seven to 14 years (mean of 10 years). Primary outcome measures were the DuPaul AD/HD Rating Scale (assessed by the teacher) and the Clinical Global Improvement Score (assessed by the blinded clinician).
At endpoint, nine of 17 subjects on guanfacine were blindly rated as "much improved" or "very much improved" compared to 0 of 17 on placebo. Guanfacine was associated with a 37 percent improvement of AD/HD symptoms. --------------------------------------------------------------------------------------------- Copyright © 1999 P\S\L Consulting Group Inc. All rights reserved. Republication or redistribution of P\S\L content is expressly prohibited without the prior written consent of P\S\L. P\S\L shall not be liable for any errors, omissions or delays in this content or any other content on its sites, newsletters or other publications, nor for any decisions or actions taken in reliance on such content. --------------------------------------------------------------------------------------------- This news story was printed from *Doctor's Guide to the Internet* located at http://www.docguide.com --------------------------------------------------------------------------------------- Return to News Story Page This site is maintained by webmaster@pslgroup.com Please contact us with any comments, problems or bugs. All contents Copyright (c) 1998 P\S\L Consulting Group Inc. All rights reserved.