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Title: Stenting for Radiation-Induced Stenosis of Extracranial Arteries Is Successful: Presented at EuroStroke
URL: http://www.pslgroup.com/dg/221B8E.htm
Doctor's Guide
May 21, 2008

By Ed Susman

NICE, France -- May 21, 2008 -- Doctors can successfully stent the head arteries of patients who are symptomatic for strokes and transient ischaemic attacks (TIAs) if the stenoses were caused by previous radiation for the treatment of malignancies, according to research presented here at the 17th European Stroke Conference (EuroStroke).

"Long-term survivors of primary head and neck malignancies are prone to refractory TIAs and strokes from radiation-induced extracranial stenoses that are not amenable for endarterectomy," said Thomas W. Leung, MD, Associate Professor of Medicine, Division of Neurology, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.

Dr. Leung and his colleagues performed angioplasty-plus-stenting procedures on 50 consecutive patients between January 2006 and December 2007. The doctors implanted 60 stents in the 50 patients in the study: 13 in common carotid arteries; 46 in proximal internal carotid arteries; and 1 in the vertebral-artery ostium.

The patients recruited for the study had at least a 70% stenosis of extracranial arteries believed to exist as a result of radiation therapy for previous disease. Technical success was achieved in all of the patients, Dr. Leung said in his poster presentation here on May 14. He defined technical success as the ability to reduce a patient's stenosis to less than 30% of the lumen of the blood vessel.

"The 30-day stroke and death outcome was 2%," said Dr. Leung. "One patient suffered a [TIA] during that period. In a mean follow-up of 14 months, no further TIAs or strokes were recorded."

"Stenting appears to be an effective treatment for symptomatic radiation-induced extra-cranial stenosis," Dr. Leung concluded. He also suggested that synchronous angioplasty for bilateral lesions was feasible.


[Presentation title: Angioplasty With Stent for Post-Irradiation Extra-Cranial Stenosis.]

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