To print: Select File and then Print from your browser's menu --------------------------------------------------------------------------------------- Title: DG DISPATCH - APS: Osteoarthritis Pain Relieved By Topical Civamide URL: http://www.pslgroup.com/dg/13DF62.htm Doctor's Guide October 25, 1999
By Mona Hughes Special to DG News
FORT LAUDERDALE, FL -- October 25, 1999 -- New research shows topical civamide is effective in reducing pain associated with primary, post-traumatic osteoarthritis of the knee.
The researchers were Joel E. Bernstein and Scott B. Phillips, of Winston Laboratories; Rashid Khairi, of Physicians Research Group; and Charles Birbara, of Clinical Pharmacology Study Group. The researchers studied civamide (cis-8-methyl-N-vanilly1-6-nonenamide), a vanilloid receptor agonist and neuronal calcium channel blocker that inhibits the release of excitatory neurotransmitters and depletes neurons of their neuropeptide contect.
In a double-blind, vehicle-controlled, parallel study, researchers recruited 179 patients (at least 40 years of age) with moderate to severe, primary or post-traumatic osteoarthritis (OA) of the knee. They applied either 0.075 percent civamide cream or cream vehicle QID to the knees for four weeks.
The results show that, after seven days of treatment, civamide-treated patients had nearly a 40 percent reduction in pain, evaluated by the visual analogue scale (VAS). After four weeks of treatment, pain was reduced by a mean of 55 percent, with statistically significant reductions in knee pain observed for civamide treated joints versus those treated with vehicle for all four efficacy variables measured.
The investigators reported that the only side effect associated with civamide was transient burning and stinging reactions at the application sites. They concluded that civamide 0.075 percent cream is a safe and effective treatment for pain associated with OA of the knees. --------------------------------------------------------------------------------------------- Copyright © 1999 P\S\L Consulting Group Inc. All rights reserved. Republication or redistribution of P\S\L content is expressly prohibited without the prior written consent of P\S\L. P\S\L shall not be liable for any errors, omissions or delays in this content or any other content on its sites, newsletters or other publications, nor for any decisions or actions taken in reliance on such content. --------------------------------------------------------------------------------------------- This news story was printed from *Doctor's Guide to the Internet* located at http://www.docguide.com --------------------------------------------------------------------------------------- Return to News Story Page This site is maintained by webmaster@pslgroup.com Please contact us with any comments, problems or bugs. All contents Copyright (c) 1998 P\S\L Consulting Group Inc. All rights reserved.