To print: Select File and then Print from your browser's menu --------------------------------------------------------------------------------------- Title: Combination of Sunlight Exposure, Low Antioxidant Levels May Place Older Adults at Risk for Eye Disease URL: http://www.pslgroup.com/dg/22EBBA.htm Doctor's Guide October 13, 2008
CHICAGO -- October 13, 2008 -- A European study suggests that the combination of low plasma levels of antioxidants and blue light exposure from the sun is associated with certain forms of the eye disease age-related macular degeneration (AMD), according to a report in the October issue of Archives of Ophthalmology, one of the JAMA/Archives journals. "The retina is vulnerable to the damaging effects of light," the authors write as background information in the article. "While wavelengths in the UV radiation range are largely absorbed by the cornea and lens, the retina is exposed to visible light, including blue light." Animal and laboratory studies suggest blue light may damage the retina and contribute to the development of AMD, which occurs when the area of the retina (macula) responsible for sharp vision deteriorates. Antioxidant enzymes -- including vitamins C and E, the carotenoids (lutein and zeaxanthin) and zinc -- may protect against the harmful effects of blue light on the retina. Astrid E. Fletcher, Ph.D., of the London School of Hygiene & Tropical Medicine, and colleagues measured levels of these nutrients in the blood of 4,753 older adults (average age 73.2) who were part of the European Eye Study. Participants also were interviewed about their lifetime sunlight exposure and had photographs taken of their retinas to detect AMD. Of the 4,400 participants with complete information available, 2,117 did not have AMD, 101 had neovascular (advanced, involving the formation of new blood vessels) AMD and 2,182 had early-stage AMD. Overall, there was no association between blue light exposure and neovascular or early AMD. However, blue light exposure was associated with neovascular AMD in the one-fourth of individuals with lowest antioxidant levels. "In particular, the combination of blue light exposure in the presence of low levels of zeaxanthin, alpha-tocopherol [vitamin E] and vitamin C was associated with a nearly 4-fold odds ratio of neovascular AMD," the authors write. Key recommendations from the results include ensuring the intake of key antioxidants, which can be accomplished by consuming recommended dietary intake levels of vitamin C and zinc and increasing consumption of carotenoid-rich fruits and vegetables, the authors note. In addition, individuals should take steps to reduce the exposure of the retina to blue light, such as wearing broad-brimmed hats and sunglasses when outdoors. "In the absence of cost-effective screening methods to identify people in the population with early AMD, we suggest that recommendations on ocular protection and diet target the general population, especially middle-aged people," they conclude. (Arch Ophthalmol. 2008; 126[10]:1396-1403. Available pre-embargo to the media at www.jamamedia.org.) Editor's note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc. SOURCE: Archives of Ophthalmology --------------------------------------------------------------------------------------------- Copyright © 1999 P\S\L Consulting Group Inc. All rights reserved. Republication or redistribution of P\S\L content is expressly prohibited without the prior written consent of P\S\L. P\S\L shall not be liable for any errors, omissions or delays in this content or any other content on its sites, newsletters or other publications, nor for any decisions or actions taken in reliance on such content. --------------------------------------------------------------------------------------------- This news story was printed from *Doctor's Guide to the Internet* located at http://www.docguide.com --------------------------------------------------------------------------------------- Return to News Story Page This site is maintained by webmaster@pslgroup.com Please contact us with any comments, problems or bugs. All contents Copyright (c) 1998 P\S\L Consulting Group Inc. All rights reserved.