To print: Select File and then Print from your browser's menu --------------------------------------------------------------------------------------- Title: Testosterone, Not Oestrogen, Predictor of Metabolic Syndrome in Older Women URL: http://www.pslgroup.com/dg/2269B2.htm Doctor's Guide July 29, 2008
CHICAGO -- July 29, 2008 -- As testosterone progressively dominates the hormonal milieu during the menopausal transition, the prevalence of metabolic syndrome increases, according to a new study published in the July 28 issue of the Archives of Internal Medicine. The longitudinal, 9-year study included 949 women who participated in the Study of Women's Health Across the Nation (SWAN) trial in the United States. The study showed that the incidence of metabolic syndrome increased progressively from 6 years before to 6 years after the final menstrual period, independent of aging and other known cardiovascular disease risk factors. The increase is steeper during the menopausal transition compared with the postmenopausal years. "Menopause-related testosterone predominance appears to be implicated as a key hormonal change that is associated with the incidence of metabolic syndrome," said lead investigator Imke Janssen, PhD, Department of Preventive Medicine, Rush University Medical Center, Chicago, Illinois. It was previously thought that oestrogen exerted a direct positive effect on cardiovascular disease risk in women, a benefit that was lost as women transitioned from a premenopausal to a postmenopausal state and experienced a loss of oestrogen. "Our study data show that the change in oestrogen level is, at best, a weak and nonsignificant predictor of metabolic syndrome risk," said Dr. Janssen. "A more likely story is that the progressive testosterone predominance exerts a direct negative effect on cardiovascular risk." SOURCE: Rush University Medical Center --------------------------------------------------------------------------------------------- Copyright © 1999 P\S\L Consulting Group Inc. All rights reserved. Republication or redistribution of P\S\L content is expressly prohibited without the prior written consent of P\S\L. P\S\L shall not be liable for any errors, omissions or delays in this content or any other content on its sites, newsletters or other publications, nor for any decisions or actions taken in reliance on such content. --------------------------------------------------------------------------------------------- This news story was printed from *Doctor's Guide to the Internet* located at http://www.docguide.com --------------------------------------------------------------------------------------- Return to News Story Page This site is maintained by webmaster@pslgroup.com Please contact us with any comments, problems or bugs. All contents Copyright (c) 1998 P\S\L Consulting Group Inc. All rights reserved.