To print: Select File and then Print from your browser's menu --------------------------------------------------------------------------------------- Title: Ductal Carcinoma With Lobular Features Differs From Invasive Ductal Carcinoma: Presented at ASCP URL: http://www.pslgroup.com/dg/22EFAE.htm Doctor's Guide October 17, 2008
By Maggie Schwarz BALTIMORE, Md -- October 17, 2008 -- Ductal carcinoma with lobular features is presenting a different clinical and pathological picture from invasive ductal carcinoma, researchers reported here at the American Society for Clinical Pathology (ASCP) 2008 Annual Meeting. In their study, Paul H. Hartel, MD, Davis Memorial Hospital, Elkins, West Virginia, and colleagues characterised the hormone receptor and human epidermal growth factor receptor 2 (HER2/neu) expression of ductal carcinoma with lobular features. Dr. Hartel discussed the results in a presentation on October 16. "Invasive lobular carcinoma is more frequently oestrogen receptor- and progesterone receptor-positive and HER2/neu-negative than invasive ductal carcinoma. A greater number of patients with invasive lobular carcinoma receive adjuvant endocrine therapy," he explained. "We decided to study these tumours because distinguishing them carries inherent treatment implications," he added. Using light microscopy, the researchers identified 131 cases of invasive ductal carcinoma, 26 cases of invasive ductal carcinoma with lobular features, and 15 cases of invasive lobular carcinoma. They also performed standardised immunohistochemistry for oestrogen receptors, progesterone receptors, and HER2/neu, with a subset of tumours evaluated for Ki67 and p53 expression. Immunohistochemistry was blindly image analysed for the cellular percentage and intensity of expression. Patients with invasive ductal carcinoma were a mean age of 56 years, and mean tumour size was 2.4 cm; 10% of samples were modified Bloom-Richardson (mBR) grade 1, 50% were grade 2, and 40% were grade 3. Patients with invasive ductal carcinoma with lobular features were a mean age of 63 years, and mean tumour size was 2.2 cm; mBR grades were 1 in 19%, 2 in 62%, and 3 in 19%. Patients with invasive lobular carcinoma were a mean age of 64 years and mean tumour size was 2.9 cm; mBR grades were 1 in 13%, 2 in 53%, and 3 in 34%. Patients with invasive ductal carcinoma with lobular features and invasive lobular carcinoma were older than patients with invasive ductal carcinoma (P = .04 and P = .78, respectively). While tumour sizes were similar in the 3 groups, the spectrum of mBR grade for invasive ductal carcinoma with lobular features was intermediate between invasive ductal carcinoma and invasive lobular carcinoma (P = .08). Oestrogen intensity was similar for invasive ductal carcinoma with lobular features and invasive lobular carcinoma groups and higher than invasive ductal carcinoma group (P < .01). Oestrogen receptor percentages showed a similar trend. HER2/neu index score and intensity were higher for invasive ductal carcinoma than for invasive lobular carcinoma (P = .02), while invasive ductal carcinoma with lobular features was intermediate. "Invasive ductal carcinoma with lobular features appears to have clinical and pathological features that distinguish it from invasive ductal carcinoma," Dr. Hartel said. "Despite similar tumour size and modified Bloom-Richardson grade, invasive ductal carcinoma with lobular features has an oestrogen receptor expression profile similar to that of invasive lobular carcinoma and different from invasive ductal carcinoma." The findings, as well as treatment implications, need to be elucidated, he added. [Presentation title: Ductal Carcinoma With Lobular Features Has Distinctive Clinical and Pathologic Characteristics. Abstract P653] --------------------------------------------------------------------------------------------- Copyright © 1999 P\S\L Consulting Group Inc. All rights reserved. Republication or redistribution of P\S\L content is expressly prohibited without the prior written consent of P\S\L. P\S\L shall not be liable for any errors, omissions or delays in this content or any other content on its sites, newsletters or other publications, nor for any decisions or actions taken in reliance on such content. --------------------------------------------------------------------------------------------- This news story was printed from *Doctor's Guide to the Internet* located at http://www.docguide.com --------------------------------------------------------------------------------------- Return to News Story Page This site is maintained by webmaster@pslgroup.com Please contact us with any comments, problems or bugs. All contents Copyright (c) 1998 P\S\L Consulting Group Inc. All rights reserved.