To print: Select File and then Print from your browser's menu --------------------------------------------------------------------------------------- Title: APA: Duloxetine Has Little Effect on Body Weight URL: http://www.pslgroup.com/dg/2157F6.htm Doctor's Guide May 24, 2002
By Bruce Sylvester PHILADELPHIA, PA -- May 24, 2002 -- The investigative antidepressant duloxetine has no clinically meaningful effects on body weight in most patients, researchers reported at the annual meeting of the American Psychiatric Association (APA). "The most important implication of this research, which combines several studies, is that, overall, the effect of duloxetine is weight neutral," said Robert Brannon, MD, clinical research physician, Eli Lilly Laboratories, Indianapolis, Indiana. The investigators pooled data from seven double-blind, placebo-controlled trials in which 1,032 patients were given duloxetine 40 mg/day to 120 mg/day and 732 received placebo. Patients were treated for up to 12 weeks. The investigators also analyzed data from a 12-month, open-label, single-arm study of 1,282 patients. Patients receiving duloxetine in the placebo-controlled trials lost approximately 0.5 kg, compared with a gain of 0.2 kg for placebo subjects (p<0.001). The incidence of decreased appetite was significantly greater for duloxetine patients (6.5 percent) compared to placebo patients (2.1 percent), as was the incidence of decreased body weight (1.7 percent vs. 0.6 percent). The incidence of increased appetite was lower for duloxetine patients (1.2 percent vs. 1.5 percent), and the incidence of increased body weight was significantly lower for duloxetine patients (0.3 percent vs. 1.2 percent). In the open-label study, mean change to end point for duloxetine patients was 1.12 kg (p<0.001). The research was supported by Eli Lilly and Company. --------------------------------------------------------------------------------------------- Copyright © 1999 P\S\L Consulting Group Inc. All rights reserved. Republication or redistribution of P\S\L content is expressly prohibited without the prior written consent of P\S\L. P\S\L shall not be liable for any errors, omissions or delays in this content or any other content on its sites, newsletters or other publications, nor for any decisions or actions taken in reliance on such content. --------------------------------------------------------------------------------------------- This news story was printed from *Doctor's Guide to the Internet* located at http://www.docguide.com --------------------------------------------------------------------------------------- Return to News Story Page This site is maintained by webmaster@pslgroup.com Please contact us with any comments, problems or bugs. All contents Copyright (c) 1998 P\S\L Consulting Group Inc. All rights reserved.