Source: Spinal Cord  |  Posted 9 years ago

Withdrawing prednisone from immunosuppressive treatment accelerates bone mass recovery following successful liver transplantation.

Previous studies have suggested a major role for glucocorticoids in transplantation related osteopenia, according to investigators from the Liver Transplantation Unit at the Hospital Universitario 12 de Octubre in Madrid, Spain.

The investigators studied 20 female and 49 male non-osteoporotic patients who underwent orthotopic liver transplantation. Twenty-eight patients received immunosuppressive treatment of prednisone, cyclosporin A and azathioprine. Prednisone dose was tapered off and withdrawn after 36.2