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Title: Home Recorded Sleep With Fluvoxamine Similar To That Seen In Laboratory With Other Antidepressants

URL: http://www.sagepub.co.uk/journals/details/issue/abstract/ab016056.html

Journal of Psychopharmacology.Vol 14 Issue 4. "Sleep and daytime sleepiness the next day following single night-time dose of fluvoxamine, dothiepin and placebo in normal volunteers"
01/26/2001 09:32:26 AM
By Veronica Rose

Home recorded sleep findings following fluvoxamine were similar to sleep laboratory studies using other antidepressant drugs. Researchers designed a placebo-controlled, double-blind, cross-over study to establish the effects on night-time sleep, drowsiness and performance the following day. Participants included 12 normal volunteers who were given a single dose of fluvoxamine 100 mg, dothiepin 100 mg or placebo. Both drugs altered night-time sleep significantly with main effects on rapid eye movement (REM) sleep and sleep continuity. There was increased total sleep time, latency in rapid eye movement, sleep, stage 2 sleep and decreased arousal with dothiepin, which also affected wake after sleep onset and stage 1 sleep. Fluvoxamine, however, decreased total sleep and rapid eye movement times and increased wake after sleep onset. Dothiepin shortened sleep latency in daytime naps, but proved longer with fluvoxamine. This, researchers suggested, was an indication that subjects were sleepier after taking dothiepin. However, electroencephalogram (EEG) performed during performance tasks failed top make any significant distinction between drugs. Researchers also found no significant variations between the groups on their tracking performance measures or reaction time. It was noted that these tasks were designed primarily to provide them with a standard setting for monitoring continuous EEG. Consequently, they were unsuitable for detecting sleepiness effects themselves. Saccadic eye movement velocity, acceleration and deceleration indicated small, non-significant changes following administration of both drugs. There was no significant difference among the groups in mood self-ratings. Subjective measures of night-time sleep reflected the objective measures of sleep continuity. The items for difficulty and speed awakening in the morning were significantly slower and more difficult, therefore, higher in the dothiepin group.

http://www.sagepub.co.uk/journals/details/issue/abstract/ab016056.html

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