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Title: Lipoprotein Alterations Impair Vitamin E In Patients With Parenchymal Liver Cirrhosis

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Metabolism: Clinical and Experimental, 2002, Vol 51, No 5. "Impaired vitamin E status in patients with parenchymal liver cirrhosis: Relationships with lipoprotein compositional alterations, nutritional factors, and oxidative susceptibility of plasma"
05/21/2002 02:00:45 PM
By David Ball

Major factors in the reduction of serum vitamin E in patients with parenchymal liver cirrhosis are lipoprotein alterations and not, as previously thought, nutritional factors. Also, vitamin E depletion appears to be associated with an increased plasma susceptibility to oxidation, according to researchers at the Hospital Universitari de Sant Joan, Catalunya, Spain. As an important antioxidant, vitamin E protects lipoproteins and cell membranes from lipid peroxidation. In this study of 55 patients with parenchymal liver cirrhosis and 25 healthy volunteers, the investigators used high-performance liquid chromatography (HPLC) to analyse vitamin E in serum and in isolated lipoprotein fractions. Their aims were to investigate nutritional and vitamin E status in relation to compositional changes in lipoproteins, and the effects of these alterations on the patients' plasma susceptibility to copper-mediated oxidation. Measurement of plasma susceptibility to peroxidation was by incubation with Cu[²⁺, and anthropometry was used to assess nutritional status. A significant decrease, related to the degree of liver impairment, was seen in vitamin E concentration in the serum and in high-density lipoprotein (HDL) and in very low-density lipoprotein (VLDL) in cirrhotic patients. Significant correlations were found between cholesterol and vitamin E concentrations in serum as well as in all the lipoprotein fractions in cirrhotic patients. However, no significant correlations were found between any of the anthropometric indices of nutritional status and vitamin E. Significant increases were seen in the plasma maximal oxidation rate in cirrhotic patients, which was inversely related to the serum concentration of vitamin E.

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