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Title: Amylin May Help Regulate Blood Glucose Levels In Response To Exercise

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Metabolism 2002; 51(5): 657-663. "Glucoregulatory endocrine responses to intermittent exercise of different intensities: Plasma changes in a pancreatic Beta-cell peptide, amylin"
05/22/2002 08:02:00 AM
By James Adams

Amylin, a peptide hormone co-secreted with insulin by pancreatic ß cells, appears to play a role in the regulation of blood glucose levels in response to exercise. Previous studies have reported that amylin inhibits release of postprandial glucagon and insulin and modulates gastric emptying. As changes in glucagon and insulin are also important for controlling blood glucose in response to situations that elevate metabolic rate, investigators hypothesized that amylin may be involved in regulating blood glucose in response to exercise. The investigators, from multiple institutions including Southeastern Louisiana University in Hammond, Louisiana, and Amylin Pharmaceuticals in San Diego, California, United States, studied seven well-trained male subjects who completed an intermittent exercise program on a treadmill at progressive intensities of 60, 75, 90 and 100 percent maximum oxygen consumption. Blood samples were obtained before exercise, after each progression of intensity and one hour following exercise. A control trial was also conducted without exercise. Results showed that amylin and insulin increased from baseline and peaked after an exercise intensity of 100 percent was reached. Levels remained elevated through much of the recovery period. Glucagon concentrations only increased after the maximum intensity was reached and then quickly declined. While exercise stimulates amylin secretion in well-trained individuals, the investigators conclude, more studies are needed to define the effects of higher amylin concentration on glucoregulation during exercise and recovery. This study was supported by a Faculty Development Grant and an Orr Grant from Southeastern Louisiana University.

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