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Title: Atherosclerosis in Iliac Artery Predicts Outcome of Renal Transplantation: Presented at ERA-EDTA

"Atherosclerosis in Iliac Artery Predicts Outcome of Renal Transplantation: Presented at ERA-EDTA"

By Alison Palkhivala COPENHAGEN, DENMARK -- July 17, 2002 -- The degree of atherosclerosis in the iliac artery helps predict outcome in kidney recipients. Serum lipid levels, however, do not appear to help predict the degree of atherosclerosis present in the iliac artery, according to investigators led by Dr. Ozgur Basaran, from the department of general surgery and transplantation at Baskent University Faculty of Medicine in Ankara, Turkey. The findings were presented here July 17 at the 39th annual Congress of the European Renal Association - European Dialysis and Transplant Association (ERA-EDTA). Biopsies of recipient iliac arteries and graft renal arteries were collected from patients undergoing renal transplantation. Overall, they assessed the results of 183 consecutive living-related and 51 cadaverous renal transplantations. After evaluating the biopsy specimens, Dr. Basaran's team allocated the native iliac arteries into one of four groups: normal vascular structure, presence of type II atherosclerotic lesions, presence of type IIIa or IIIb atherosclerotic lesions, or presence of both type II and IIIa lesions. They also measured patients' pre-operative serum lipid profiles and found no significant differences among the groups. Nearly one-quarter of patients experienced postoperative hemorrhage, and nearly 10 percent experienced postoperative graft renal artery stenosis. Patients with type IIIa or IIIb atherosclerotic lesions were more likely to experience postoperative hemorrhage and renal artery stenosis and less likely to have their graft survive than were patients whose biopsies showed normal vascular structure in the iliac artery. The authors concluded that patients with type IIIa or IIIb atherosclerotic lesions in their native iliac arteries experience poorer rates of graft survival and are more likely to have vascular complications during renal transplantation than patients with normal vasculature in their iliac arteries. They also noted that pre-operative serum lipid levels do not predict the degree of atherosclerosis present in the iliac artery.

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