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Title: Yohimbine Plus L-Arginine Potential Therapy For Mild To Moderate Erectile Dysfunction

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European Urology 2002 Jun;41(6):608-13.
07/31/2002 08:01:22 AM
By Alison Palkhivala

A combination of yohimbine plus L-arginine, taken as needed before intended sexual intercourse, appears to be effective for the treatment of mild to moderate erectile dysfunction, according to a prospective pilot study. The researchers hope that this approach may prove to be a useful first-line treatment for the condition. Dr. T. Lebret and colleagues from the department of urology, Hospital Foch, Suresnes, France, randomly assigned 45 men with erectile dysfunction to treatment with 6 g of L-arginine glutamate combined with 6 mg of yohimbine hydrochloride, to 6 mg of yohimbine hydrochloride alone, or to placebo, in a blinded fashion. The patients switched therapies every two weeks until they had tried each one. They took the drugs orally one to two hours before intended sexual intercourse. After the end of each two-week therapy period, the researchers tested patients using the Erectile Function Domain score of the International Index of Erectile Function (IIEF) and compared the results to those obtained during testing that was done before therapy was initiated. Changes in this score were significantly greater among patients taking yohimbine plus L-arginine compared to those taking placebo. Patients with mild to moderate erectile dysfunction responded best to this combination treatment. The authors conclude that yohimbine plus L-arginine has potential as a first-line option for mild to moderate male erectile dysfunction.

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