To print: Select File and then Print from your browser's menu

Title: Fibrogenic Cytokines May Play Role in Nephrogenic Fibrosing Dermatopathology: Presented at ASDP

"Fibrogenic Cytokines May Play Role in Nephrogenic Fibrosing Dermatopathology: Presented at ASDP"

By Alison Palkhivala Special to DG News PHOENIX, AZ -- October 15, 2002 -- A clear pattern of laboratory findings has yet to be determined in nephrogenic fibrosing dermatopathology, but new research suggests a role for fibrogenic cytokines. Lydon Dy Su, MD, a clinical assistant professor in the pathology department at University of Michigan Medical School, in Ann Arbor, Michigan, United States, reported the findings on 13 patients with nephrogenic fibrosing dermatopathology here last week at the annual meeting of the American Association of Dermatopathology (ASDP). He stated that, "nephrogenic fibrosing dermatopathology (NFD) is a newly recognised cutaneous fibrosing disorder marked by the acute onset and persistence of woody induration involving the upper and lower limbs in patients with acute or chronic renal failure." All 13 patients had developed renal failure before the disease began. Eight were on chronic haemodialysis, and two were on chronic peritoneal dialysis. Most patients had serious underlying diseases, and many were taking erythropoetin and/or cyclosporine therapy before disease onset. No laboratory findings were consistently linked to the condition, according to the researchers. However, skin biopsies did reveal the presence of microfibroblasts, which indicates a potential role for fibrogenic cytokines in this disease.

Copyright © 2009 P\S\L Consulting Group Inc. All rights reserved. Republication or redistribution of P\S\L content is expressly prohibited without the prior written consent of P\S\L. P\S\L shall not be liable for any errors, omissions or delays in this content or any other content on its sites, newsletters or other publications, nor for any decisions or actions taken in reliance on such content.