Title: Glimepiride Produces Remarkable Improvement In Insulin Resistance
|
|
To print: Select File and then Print from your browser's menu Title: Glimepiride Produces Remarkable Improvement In Insulin Resistance |
| URL: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=R Retrieve&db=PubMed&list_uids=12547850&dopt=Abstract |
|
Diabetes Care 2003;26:2:285-9. "Plasma adiponectin plays an important role in improving insulin resistance with glimepiride in elderly type 2 diabetic subjects." 02/10/2003 09:39:47 AM By Mark Greener Increased adiponectin levels contribute to the improvement in insulin resistance seen when elderly people with type 2 diabetes take glimepiride. Researchers from Nagoya University Graduate School of Medicine, Japan, treated 17 elderly patients with type 2 diabetes with glimepiride for 12 weeks. After eight weeks treatment, levels of glycosylated haemoglobin (HbA(1c)) declined from 8.4% at baseline to 6.9%. The homeostasis assessment model of insulin resistance (HOMA-IR) and levels of tumour necrosis factor-alpha also declined. On the other hand, the metabolic clearance rate of glucose, assessed using a hyperinsulinemic-euglycemic clamp, increased. Levels of plasma adiponectin also rose. No marker changed in a control group on normal treatment. The authors concluded that glimepiride remarkably improved insulin resistance without changing either extrapancreatic beta-cell function or levels of C-peptide in urine. They speculated that the increased levels of adiponectin and reduced concentrations of plasma TNF-alpha might underlie the improved insulin resistance associated with glimepiride. |
| http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=R Retrieve&db=PubMed&list_uids=12547850&dopt=Abstract |
|
Copyright © 2009 P\S\L Consulting Group Inc. All rights reserved. Republication or redistribution of P\S\L content is expressly prohibited without the prior written consent of P\S\L. P\S\L shall not be liable for any errors, omissions or delays in this content or any other content on its sites, newsletters or other publications, nor for any decisions or actions taken in reliance on such content. Go back This site is maintained by webmaster@pslgroup.com Please contact us with any comments, problems or bugs. All contents Copyright (c) 2009 P\S\L Consulting Group Inc. All rights reserved. |