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Title: Bedroom House-Mite Dust Levels Unrelated To Later Bronchial Hyper-Responsiveness

URL: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=R
Retrieve&db=PubMed&list_uids=12546336&dopt=Abstract

Annals of Allergy, Asthma, & Immunology, 2003;90:1:41-44. "Relationship of house-dust mite allergen exposure in children's bedrooms in infancy to bronchial hyperresponsiveness and asthma diagnosis by age 6 to 7."
02/04/2003 09:20:08 AM
By Elda Hauschildt

Intensive follow-up failed to find a relationship between exposure to house-dust mite (HDM) allergens in bedrooms of infants and the development of bronchial hyper-responsiveness at age six or seven years, researchers in the United States report. Levels of HDM allergens were also not related to the infants developing doctor-diagnosed asthma at age 6 or 7 years. Investigators from the Henry Ford Healthcare System in Detroit, Michigan, followed a cohort of 97 middleclass, suburban children born between 1987 and 1989, who were enrolled in the Childhood Allergy Study. The children had high cord blood immunoglobin E levels. For the first two years of the children's lives, bedroom dust samples were collected monthly and analysed for Der f 1 and Der p 1. When the children reached age 6 or 7 years, 64 underwent clinical examination, skin-prick testing and methacholine inhalation challenge. A questionnaire was used to determine which children had doctor-diagnosed asthma. Mann-Whitney testing compared Der f 1 and Der p 1 levels in the homes of children with/without bronchial hyper-responsiveness as well as those with or without asthma. A total of 1,421 dust samples were collected and analysed. No significant differences were found in mean, maximum or minimum HDM allergen levels in homes of children with/without bronchial hyper-responsiveness or with/without asthma. The researchers found HDM sensitisation was associated with doctor-diagnosed asthma, however.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=R
Retrieve&db=PubMed&list_uids=12546336&dopt=Abstract

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