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Title: Contact Sensitisation to Hair Dye Common in Adult Widespread Eczema

URL: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=R
Retrieve&db=PubMed&list_uids=12581280&dopt=Abstract

Contact Dermatitis 2002 Dec;47:6:341-4. "A clinical and patch test study of adult widespread eczema."
03/03/2003 10:18:29 AM
By David Ball

Contact sensitisation to allergens such as hair dye is common in adult widespread eczema (WE), according to Chinese researchers. Neglected widespread contact with contact allergens plays an important role in adult WE, and further studies were needed on the impact of age and gender, they suggest. In this study, the role of contact hypersensitivity (CHS) in WE was investigated, and the aetiology of WE analysed, by LF Li and J Wang of the Department of Dermatology, Peking University The Third Hospital, Beijing. Patch tests were made in 108 consecutive adult WE patients and a control group of 352 patients with suspected localised allergic contact dermatitis (ACD). Those in the WE group had a significantly greater average age than the control subjects (47.6 ą 15.0 v 39.2 ą 14.9, p < 0.01, Student's t-test). The WE group also had a higher proportion of male patients, 42.6% vs. 25.0%, p < 0.01, chi2-test. Seventy-one WE subjects, 65.7%, were found to be patch test positive. Twenty-nine of 108 WE subjects were diagnosed with ACD, including 26.9% of the WE patients and 40.8% of the PT positive patients. A further 42 subjects with at least one positive PT result were suspected of having ACD, though it was difficult to determine the relevance of PT. Two cases of food allergy, diagnosed by clinical findings and open food challenge test, were found in the remaining 37 patch test negative subjects. There was one case of atopic dermatitis. Unclassified endogenous eczema was diagnosed in 34 subjects, 31.5%. Fifteen of the 29 ACD patients were found to be ACD from widespread contact with hair dye during bathing and most of these were male. There was no difference in the total positive rates of PT between the WE group and controls (65.7% vs. 61.5%, p > 0.05, chi2-test). Neither was there any significant difference in the positive rates of common contact allergens. No difference was found between the two groups in the rate of atopy (6.5% vs. 5.1%, p > 0.01, chi2-test).

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=R
Retrieve&db=PubMed&list_uids=12581280&dopt=Abstract

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