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Title: Once Daily Coat-Core Nifedipine Has The Advantage Over Amlodipine In Essential Hypertension

URL: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=R
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Journal of Cardiovascular Pharmacology 2003:41 Supplement 1:S77-81. "Effects of long-acting calcium channel antagonists on neurohumoral factors: comparison of nifedipine coat-core with amlodipine"
04/16/2003 09:21:21 AM
By Veronica Rose

Nifedipine formulations, administered once daily, are more effective than are amlodipine for the management of hypertensive patients, according to researchers. Acknowledging that calcium channel antagonists can result in a poor prognosis through sympathetic hyperactivity, the researchers - from Shiga University of Medical Science, Otsu, Japan - undertook a comparative study of the two drugs in 36 patients with essential hypertension. Patients who had been receiving sustained-release nifedipine were given amlodipine instead and those who had previously been treated with amlodipine now received coat-core nifedipine. The researchers noted that hypertensive symptoms had no significant effect among patients receiving either amlodipine nor coat-core nifedipine. But, the plasma levels of norepinephrine, renin, and aldosterone were noticeably lower in patients whose sustained -release nifedipine was substituted for amlodipine. There was also no significant change in the plasma levels of norepinephrine, renin and aldosterone following substitution of amlodipine by coat-core nifedipine. The researchers concluded that coat-core nifedipine may not increase the sympathetic nerve activity seen in amlodipine at the effective anti-hypertensive concentrations of the two drugs. In addition, the nifedipine formulations duration of action is an important determinant for nifedipine- induced hyperactivity in the reflex sympathetic nerve and the renin-angiotensin systems.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=R
Retrieve&db=PubMed&list_uids=12688402&dopt=Abstract

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