Case - Rapid and Persistent Selection of the K103N Mutation as a Majority Quasispecies in a HIV1-Patient Exposed to Efavirenz for Three Weeks: A Case Report and Review of the Literature

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Rapid and Persistent Selection of the K103N Mutation as a Majority Quasispecies in a HIV1-Patient Exposed to Efavirenz for Three Weeks: A Case Report and Review of the Literature

Presented by:	Journal of Medical Case Reports / Ennio Polilli, Giustino Parruti, Luana Cosentino, Federica Sozio, Annalisa Saracino, Augusta Consorte, Gioacchino Angarano, Francesco Di Masi, Elena Mazzotta and Paolo Fazii
Summary points:	A 55-year-old Caucasian male was switched to efavirenz, zidovudine and lamivudine in 2003, while on viral suppression in his first-line highly active anti-retroviral treatment regimen. In 2005, the patient interrupted his medications 3 weeks after simplification. Genotyping resistance testing assay is described. The authors discuss the need to rule out the presence of the K103N mutation after even minimal exposure to efavirenz.
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