Rapid and Persistent Selection of the K103N Mutation as a Majority Quasispecies in a HIV1-Patient Exposed to Efavirenz for Three Weeks: A Case Report and Review of the Literature
Presented by:
Journal of Medical Case Reports / Ennio Polilli, Giustino Parruti, Luana Cosentino, Federica Sozio, Annalisa Saracino, Augusta Consorte, Gioacchino Angarano, Francesco Di Masi, Elena Mazzotta and Paolo Fazii
Summary points:
A 55-year-old Caucasian male was switched to efavirenz, zidovudine and lamivudine in 2003, while on viral suppression in his first-line highly active anti-retroviral treatment regimen. In 2005, the patient interrupted his medications 3 weeks after simplification. Genotyping resistance testing assay is described. The authors discuss the need to rule out the presence of the K103N mutation after even minimal exposure to efavirenz.
Rapid and Persistent Selection of the K103N Mutation as a Majority Quasispecies in a HIV1-Patient Exposed to Efavirenz for Three Weeks: A Case Report and Review of the Literature
