| Summary points: | A 82-year-old Caucasian female presents with pronounced nephrotic syndrome. About 6 weeks prior, she had received a combination vaccination for tetanus, diphtheria, and poliomyelitis. Medical history, physical examination, laboratory data, chest radiograph, urinalysis, renal biopsy, and treatment are described. The authors discuss the first reported case of minimal change nephrotic syndrome (MCNS) following a combined tetanus-diphtheria-poliomyelitis-vaccination, and suggest that vaccination and the resulting stimulations of the immune system might cause MCNS and other severe immune reactions. |