| Summary points: | A 25-year-old woman treated with fluconazole 150 mg once a month for recurrent vaginal candidiasis develops red erythematous macules on her right and left popliteal fossa and her right upper lip after taking her second, third, and fifth dose, respectively. Patches were similar in appearance and faded but hyperpigmentation developed. Family history, local provocation, and skin biopsy are described; images provided. The authors discuss a rare case of fixed drug eruption due to fluconazole, which they caution may be misdiagnosed and mistreated since this is an uncommon side effect. |