| Summary points: | A 57-year-old Caucasian woman with treatment-resistant chronic schizophrenia developed acute renal failure following initiation of treatment with clozapine. The adverse reaction occurred after only 4 doses of the drug had been administered (titrated from 12.5 to 25 mg/day). After clozapine withdrawal, the patient's renal function returned to normal with no other changes to medication. The authors discuss a rare, but important case of clozapine-induced interstitial nephritis. |