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Segmental Tandem Triplication of the MLL Gene in an Intravascular Large B-Cell Lymphoma With Multisystem Involvement: A Comprehensive Morphologic, Immunophenotypic, Cytogenetic, and Molecular Cytogenetic Antemortem Study
| Presented by: | Archives of Pathology & Laboratory Medicine / Jeremy Deisch, MD, Franklin "Buddy" Fuda, DO, Weina Chen, MD, PhD, Nitin Karandikar, MD, PhD, Arnaldo A. Arbini, MD, Xin J. Zhou, MD and Huan-You Wang, MD, PhD |
| Summary points: | A 47-year-old Vietnamese man with no significant medical history presents to the emergency department with worsening exertional dyspnoea, occasional chest pain at rest, lower extremity pain, oedema, and numbness. Physical examination, laboratory data, imaging findings, bone marrow biopsy, a percutaneous kidney biopsy, and a transbronchial lung biopsy are described. After a diagnosis of intravascular large B-cell lymphoma (IVLBCL), conventional cytogenetic analysis and fluorescence in situ hybridisation with a mixed lineage leukaemia (MLL) probe set confirmed the presence of 3 copies of the MLL gene on the derivative chromosome 11. The authors discuss the role of MLL in lymphomagenesis of IVLBCL, at least in a subset of cases. |
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