| Summary points: | A 21-year-old woman with cystic fibrosis (CF) and a totally implantable venous access device (TIVAD) initially presents with a deterioration in her oxygen saturation; 1 month later she presents with transient expressive dysphasia and a right-sided haemiparesis. Lung function, thoracic computed tomography (CT) scan, brain CT, contrast echocardiogram, and cardiac magnetic resonance imaging findings are described; images provided. The authors discuss severe hypoxaemia caused by thrombus formation in the right atrium and stress the need to consider right-to-left shunt in chronic respiratory diseases when hypoxaemia is disproportionate to the degree of impaired lung function. |