| Summary points: | A 50-year-old female presents with lower left limb pain and dyschaesia for 3 months. Computed tomography, surgery, immunohistochemistry, and pathology are described; images provided. The authors discuss the difficulties associated with differentiating gastrointestinal stromal tumours from other spindle cell tumours, and the subsequent need for immunohistochemistry, examination of c-KIT gene amplification, and sequencing. |