| Summary points: | A 57-year-old Caucasian female is admitted to hospital with nausea, lethargy, dehydration, reduced appetite, and renal impairment 2 weeks after receiving her first cycle of cisplatin and 5-fluorouracil (5-FU) for cervical carcinoma. Detailed medical history, laboratory tests, head computed tomography with contrast, brain magnetic resonance imaging, lumbar puncture, and electroencephalogram are described; images provided. The authors discuss the diagnosis and treatment of encephalopathy from low dose 5-FU, which is not well documented in the literature. |