| Summary points: | A 26-year-old with irritable bowel syndrome presents with long-standing fatigue that started after she started a new job. This interactive, audiovisual case presentation details the patient's symptoms, diagnostic investigations, and management. The authors discuss the relationship among comorbid illnesses, relationship factors, and sexual dysfunction, the types of sexual dysfunction and their interrelationship, and the influence of cultural factors on the patient's interpersonal experience and intrapersonal behaviours. |