| Summary points: | A 48-year-old Caucasian male with DOOR (Deafness, Onycho-Osteodystrophy, and mental Retardation) syndrome, and a history of obesity, epilepsy, cerebral palsy, recurrent chest infections, asthma, gastroesophageal reflux, and hypertension undergoes 2 dental treatments under anaesthetic care. Anaesthetic preassessment, entropy monitoring, and airway management are described; images provided. The authors discuss the challenges of anaesthetic management in patients with DOOR syndrome. |