Scroll Up
Scroll Down
Play Play Play Play
Unregistered User
Click here if this is not your Personal Edition
 
Contact Us | Free E-Mail Updates | Journals | Register a colleague
 
 
Infertility
 
   
 
SEARCH   
Doctor's Guide Free CME
Medline
Congress Resource Centre
 

 EXPLORE :
   Most Read News
 All News  All News
 All Webcasts / CME  All Webcasts / CME
 All Cases  All Cases
 Congress Resource Centre  Congress Resource Centre
 All Medical Resources  All Medical Resources
 Medical  My Personal Edition



Warning | Privacy

 

 
 Recent news - Infertility
    TopAbstracts in Infertility 07/01/2008 - (DGNews)
    Researchers Identify Predictive Factors for Successful IVF - (DGNews)
    TopAbstracts in Infertility 06/03/2008 - (DGNews)
    Study Suggests Chemotherapy Diminishes Fertility in Breast Cancer Patients - (DGNews)
    In Vitro Fertilisation Largely Overcomes Infertility in Women Under 40: Presented at ACOG - (DGDispatch)

    News archive

     Recent webcasts/CME

      Webcasts/CME archive

       Recent cases - Infertility
        Secondary Infertility Caused by the Retention of Fetal Bones After Abortion: A Case Report
        Resolution of Male Infertility Following Anti-Tumor Necrosis Factor (Infliximab): A Case Report
        First Successful Case of In Vitro Fertilization-Embryo Transfer with Venom Immunotherapy for Hymenoptera Sting Allergy
        Monochorionic-Triamniotic Triplet Pregnancy After Intracytoplasmic Sperm Injection, Assisted Hatching, and Two-Embryo Transfer: First Reported Case Following IVF
        Intrauterine Pregnancy Following Low-Dose Gonadotropin Ovulation Induction and Direct Intraperitoneal Insemination for Severe Cervical Stenosis

        Cases archive
          




        my personal edition > infertility > news
        divider

          E-Mail this DGReview to a colleague

        DGReview


        Aromatase Inhibition Corrects Endocrinopathy In Infertile Men

        A DGReview of :"Evidence Of A Treatable Endocrinopathy In Infertile Men"
        Journal of Urology

        04/09/2001
        By David Loshak


        Aromatase inhibition can significantly improve serum parameters in men who are infertile due to the absence or deficiency of sperm.

        Investigators at the Center for Biomedical Research and other institutions in New York, US, have found that this technique can correct a decreased serum testosterone-to-oestradiol ratio which is characteristic of an endocrinopathy in men with severe male factor infertility.

        The serum testosterone-to-oestradiol ratios of 63 such men or men with hypergonadotropic hypogonadism (mean follicle-stimulating hormone 21.2 ± 1.8) were compared with those of age-matched, fertile male controls.

        Of the 63 affected men, 43 were azoospermic with biopsy-proved severe male infertility. The other 20 were oligospermic.

        The men with the lowest ratios, those below the 20th percentile, were given twice daily 50-100 mg. oral doses of the aromatase inhibitor testolactone. Testosterone-to-oestradiol ratios and semen analyses were evaluated during therapy.

        The investigators found that men with severe infertility had significantly lower testosterone (328 versus 543 ng/dl) and significantly higher oestradiol (58.4 versus 43.5 ng/l) than the fertile controls. As a result, the infertile men had much lower testosterone-to-oestradiol ratios.

        These abnormalities were corrected in the 45 men who received testolactone and their testosterone-to-oestradiol ratios rose into the normal range.

        Semen analyses were considered evaluable only in men with sperm in the ejaculate before aromatase inhibitor treatment. Semen analyses before and during testolactone treatment in 12 oligospermic men showed significant increases in sperm concentration, which rose from 16.1 to 28.9 million sperm per ml, and in motility, which rose correspondingly, from 27.1 percent to 45.3 percent.
        Journal of Urology 2001;165:837-841. "Evidence Of A Treatable Endocrinopathy In Infertile Men"

        E-Mail this DGReview to a colleague   To print, use this version






        All contents Copyright (c) 1995-2008 Doctor's Guide Publishing Limited. All rights reserved.



        The NTK initiative. Physicians helping physicians identify Need-To-Know science
           Feedback
        Please rate this article: Strongly DISAGREE...Strongly AGREE NTK logo
        Question 1 - Physicians need to become aware of this information as soon as possible. Question 2 - This information is likely to have an impact on the way physicians practice medicine.
        1
        2
        3
        4
        5
        6
        7
        Send