Scroll Up
Scroll Down
Play Play Play Play
Unregistered User
Click here if this is not your Personal Edition
 
Contact Us | Free E-Mail Updates | Journals | Register a colleague
 
 
Breast Cancer
 
   
 
SEARCH   
Doctor's Guide Free CME
Medline
Congress Resource Centre
 

 EXPLORE :
   Most Read News
 All News  All News
 All Webcasts / CME  All Webcasts / CME
 All Cases  All Cases
 Congress Resource Centre  Congress Resource Centre
 All Medical Resources  All Medical Resources
 Medical  My Personal Edition



Warning | Privacy

 

 
 Recent news - Breast Cancer
    TopAbstracts in Breast Cancer 11/24/2009 - (DGNews)
    Short-Term Follow-Up a Reasonable Alternative to Immediate Biopsy of Palpable Breast Lesions - (DGNews)
    Optical Coherence Tomography Identifies Surgical Margins for Breast Cancer Intraoperatively - (DGNews)
    TopAbstracts in Breast Cancer 11/17/2009 - (DGNews)
    US Panel Ups Age for Routine Breast Cancer Screening From 40 to 50 - (DGNews)

    News archive

     Recent webcasts/CME - Breast Cancer
    Cutaneous Metastasis of Breast Carcinoma Presenting as Alopecia Neoplastica

    Webcasts/CME archive

     Recent cases - Breast Cancer
      Breast Pseudotumoral Radionecrosis as a Late Radiation-Induced Injury: A Case Report
      Large Family with Both Parents Affected by Distinct BRCA1 Mutations: Implications for Genetic Testing
      Bilateral Swollen Eyelids Occurring During Adjuvant Treatment with Tamoxifen for Early Breast Cancer
      Ruptured Gallbladder as the First Presentation of Breast Cancer
      Synchronous Infiltrating Ductal Carcinoma and Primary Extramedullary Plasmacytoma of the Breast

      Cases archive
        




      my personal edition > breast cancer > news
      divider

        E-Mail this DGReview to a colleague

      DGReview


      Systemic Chemotherapy For Breast Cancer, Lymphoma Can Affect Cognitive Functioning

      A DGReview of :"Neuropsychologic Impact of Standard-Dose Systemic Chemotherapy in Long-Term Survivors of Breast Cancer and Lymphoma"
      Journal of Clinical Oncology (JCO)

      01/21/2002
      By Veronica Rose


      Systemic chemotherapy can negatively impact on cognitive function according to the results of specific tests, say American researchers. These include measurements of standardized neuropsychologic tests and self reported memory changes.

      There are suggestions, however, that these cognitive deficits may only be experience by a subgroup of survivors.

      A research team at New Hampshire Hospital in Concord, New Hampshire compared the neuropsychological functioning of long term survivors of breast cancer and lymphoma who had received either standard- dose systemic chemotherapy or local therapy only.

      Participants included long-term survivors from breast cancer or lymphoma, diagnosed five years previously, who were not now receiving cancer therapy and were disease free since completion of systemic chemotherapy. Thirty-five patients (aged 59.1 ± 10.7 years) had breast cancer, and 36 (aged 55.9 ± 12.1 years) had lymphoma. Additional participants also included patients who had received local therapy only: 35 patients with breast cancer (aged 60.6 ± 10.5 years) and 22 with lymphoma (aged 48.7 ± 11.7 years).

      All patients completed a battery of neuropsychologic and psychologic tests according to the Centre for Epidemiological Study- Depression, Spielberger State-Trait Anxiety Inventory and Fatigue Symptom Inventory.

      Survivors treated with systemic chemotherapy scored notably lower on the battery of neuropsychologic tests by comparison with those who received local treatment only according to multivariate analysis of variance, controlling for age and education. This was particularly true in the domains of verbal memory (P< .01) and psychomotor functioning (P< .03).

      Researchers concluded that the patients were also more likely to score in the lower quartile on the Neuropsychological Performance Index (39 vs 14 percent, P <.01) and to self report greater problems with their working memory on the Squire Memory Self- Rating Questionnaire (P <.02).
      Journal of Clinical Oncology January 2002 Vol 20 No 2 pp 485-493. "Neuropsychologic Impact of Standard-Dose Systemic Chemotherapy in Long-Term Survivors of Breast Cancer and Lymphoma"

      E-Mail this DGReview to a colleague   To print, use this version






      All contents Copyright (c) 1995-2009 Doctor's Guide Publishing Limited. All rights reserved.



      The NTK initiative. Physicians helping physicians identify Need-To-Know science
         Feedback
      Please rate this article: Strongly DISAGREE...Strongly AGREE NTK logo
      Question 1 - Physicians need to become aware of this information as soon as possible. Question 2 - This information is likely to have an impact on the way physicians practice medicine.
      1
      2
      3
      4
      5
      6
      7
      Send