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Trans-Fatty Acids In Diet May Be Associated With First Heart Attack
A DGReview of :"Cell Membrane Trans -Fatty Acids and the Risk of Primary Cardiac Arrest"
Circulation
02/20/2002
By Robert Short
Dietary intake of total trans-fatty acids is modestly associated with heart attack. However, trans-isomers of linoelic acid show a larger increase in the risk of a first heart attack.
These were the findings of a population-based case-control study carried out in Seattle, Washington, United States. The investigators looked specifically at the association of trans-fatty acid intake, assessed through a biomarker, with the risk of primary cardiac arrest.
Dr Rozenn Lemaitre stressed that the associations they found in the study between cardiac arrest and trans-isomers of linoleic acid need to be confirmed in future studies that distinguish between trans-isomers of linoleic acid and trans-isomers of oleic acid. Dr Lemaitre is based at the Cardiovascular Health Research Unit, Department of Medicine, University of Washington.
In the study, 179 people aged 25 to 74 years who had cardiac arrests out of hospital and were attended by paramedics, were compared with 285 matched community controls. All participants in the study were previously free of clinically diagnosed heart disease.
It was found that higher total trans-fatty acids in red blood cell membranes was associated with a modest increase in the risk of primary cardiac arrest (after adjustment for medical and lifestyle risk factors. The odds radio was 1.5.
However, trans-isomers of oleic acid were not associated with risk; odds radio 0.8, whereas higher levels of trans-isomers of linoleic acid were associated with a three-fold increase in risk; odds ratio 3.1.
Circulation 2002;105:697.
"Cell Membrane Trans -Fatty Acids and the Risk of Primary Cardiac Arrest"
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