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|  my personal edition > dermatology other > news  
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DGDispatch 
Signs Of Premature Aging Significantly Improved With Daily Tazarotene Cream: Presented at AADBy Pamela Harrison Special to DG News NEW ORLEANS, LA -- February 26, 2002 -- Premature aging of the skin are significantly improved by daily application of tazarotene cream 0.1%, according to study results presented during the 60th annual meeting of the American Academy of Dermatology. In the placebo-controlled, double-blind study, Dr. T. Phillips, from Boston University School of Medicine, and colleagues from various institutions, evaluated the long-term safety and efficacy of tazarotene cream 0.1% and sunscreen applied to the face once a day for 52 weeks. A total of 563 patients were involved in the study, which consisted of an initial 24-week, double-blind, vehicle-controlled period during which patients used either active or vehicle cream once a day, followed by a 28-week, open-label study during which all patients applied the active cream daily to the face. At the end of the double-blind period at week 24, significantly more patients using the active cream showed improvement by at least one grade in a variety of variables assessed, including fine wrinkling, mottled hyperpigmentation, lentigines, elastosis, irregular depigmentation, tactile roughness, coarse wrinkling, pore size and overall integrated assessment of photodamaged skin. During the open-label study, the proportion of patients who had used tazarotene cream initially, and who had already improved by at least one grade from baseline, continued to increase, while patients who were initially treated with vehicle also showed distinct improvement upon subsequent treatment with active therapy, they add. "Over the entire 52 weeks, the most frequent adverse events were signs and symptoms of local skin irritation, which were mainly of mild to moderate severity, and systemic exposure to tazarotene appeared to be very limited," the authors indicated. "Tazarotene cream 0.1%, applied once daily, is effective in the topical treatment of signs and symptoms of premature aging of the skin due to overexposure to the sun, and it has an acceptable safety profile," they concluded.
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