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my personal edition > menopause > news
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DGReview
Ovulatory Cycles Not Affected By Isoflavones Supplement
A DGReview of :"A Randomized Isoflavone Intervention among Premenopausal Women"
Cancer Epidemiology, Biomarkers & Prevention
03/21/2002
By Harvey McConnell
A year long study has found that isoflavones given to premenopausal women does not affect their ovulatory cycles.
Investigators undertook the study in light of indications that isoflavones phytoestrogens contained in soy foods, may play a role in the prevention of breast cancer.
In a randomized double-blind trial, researchers from the Cancer Research Center, Honolulu. Hawaii, and the University of California at Los Angeles, studied the one year ovulatory cycles among 34 premenopausal women. The two groups were comparable at baseline except for a small difference in age.
The women were given 100 mg of isoflavones a day, or placebo. The investigators assessed compliance with the regimen by measuring increased isoflavone in the urine of women in the intervention cohort.
Blood samples were taken five days after ovulation at baseline and then at months one, three, six and 12. Immunoassay was used to quantify their serum levels of estrone, estradiol, estrone sulfate, progesterone, sex hormone-binding globulin, follicle-stimulating hormone, and luteinizing hormone, and free estradiol was calculated by the investigators.
There were no significant changes in the menstrual cycles of the cohorts during the study. Over the year of the study, investigators did not find any significant changes in hormone levels by treatment group.
At one year, there was a difference between the study cohort and the control cohort -13.0 pg/ml for estradiol and 6.9 pg/m for estrone. Results were not affected by the exclusion among the cohorts of 22 non-ovulatory cycles, or women who were noncompliant, or non-Asian women.
The investigators said their findings do not support the hypothesis that isoflavones affect the ovulatory cycles of premenopausal women over a 12 month period. At the same time, they acknowledge that isoflavones alone may have different effects on the reproductive cycle than isoflavones present in soy foods.
Cancer Epidemiology Biomarkers & Prevention 2000; 11:195-201.
"A Randomized Isoflavone Intervention among Premenopausal Women"
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