my personal edition > cardiology other > news
E-Mail this DGReview to a colleague
DGReview
Vitamin C Beneficial In Heart Disease
A DGReview of :"Vitamin C Preserves Endothelial Function in Patients with Coronary Heart Disease after a High-Fat Meal"
Clinical Cardiology
05/27/2002
By Robert Short
Vitamin C treatment has a possible role in benefiting patients with coronary heart disease by countering the adverse effects of a high-fat meal.
The postprandial serum triglyceride concentration is raised after a high-fat meal and this postprandial state is critical in atherogenesis, inducing endothelial dysfunction through an oxidative stress mechanism.
These were the findings of a study that included 74 patients with coronary heart disease and 50 people without the disease but who had risk factors. These two groups were split into subgroups: those who received 2 g of vitamin C and those who did not after eating high-fat meal.
The study was conducted by Dr Ling Liu, Department of Cardiology, Hunan University, Hunan, People's Republic of China, and co-workers.
They found that postprandial serum triglyceride concentration increased significantly at two to five hours after the high-fat meal in all groups. The fasting flow-mediated dilatation and nitroglycerin-induced dilatation of patients with coronary heart disease were impaired compared with those without disease.
Although the postprandial flow-mediated dilatation was significantly aggravated in people not taking vitamin C (both with and without heart disease), this parameter in patients and subjects taking vitamin C showed no significant change.
Clin Cardiol 2002;25:219-224.
"Vitamin C Preserves Endothelial Function in Patients with Coronary Heart Disease after a High-Fat Meal"
All contents Copyright (c) 1995-2010 Doctor's Guide Publishing Limited. All rights reserved.
| 
